Blog by Jaydev Varsani | Clinical Pharmacist at Bramley Pharmacy and Murrays Chemist
GLP-1 and GIP Receptor Agonists: Understanding Their Impact on Gallbladder Health
As the use of modern hormone-based injectable therapies for weight management increases, it’s important to understand both their benefits and their potential effects on other parts of the body — including the gallbladder.
At Bramley Pharmacy, we believe in offering medically led, structured support to all patients undergoing treatment. This includes proactive education around gallbladder health and practical advice to help minimise risks.
How These Treatments Work
Certain injectable treatments used in weight management clinics work by mimicking the effects of natural hormones in the body. These therapies often target two key hormones:
- GLP-1 (glucagon-like peptide-1)
- GIP (glucose-dependent insulinotropic polypeptide)
These hormones help regulate appetite, slow stomach emptying, support blood sugar control, and can lead to gradual weight loss when combined with appropriate lifestyle changes. While the effects of these treatments can be very positive, it’s important to be aware of how significant weight loss — especially if rapid — may influence other organs, such as the gallbladder.
Gallbladder Function and Weight Loss
The gallbladder stores and releases bile to help digest fats. Significant changes in eating patterns, digestion, or weight can sometimes affect how bile moves through the gallbladder — occasionally leading to the formation of gallstones (small cholesterol deposits).
The likelihood of gallstone formation appears to increase when weight loss is rapid or substantial, regardless of whether it’s achieved through medication, strict dieting, or surgery.
Recognising the Signs of Gallbladder Issues
Patients undergoing significant weight loss, particularly through appetite-suppressing treatments, should be aware of symptoms that might indicate gallbladder dysfunction:
- Pain in the upper right side of the abdomen (often after eating fatty foods)
- Nausea, bloating, or indigestion
- Pain between the shoulder blades or under the right shoulder
- Fever or chills
- Jaundice (yellowing of the eyes or skin)
If you experience any of these, it’s important to consult a healthcare professional without delay.
Minimising Gallbladder Risk During Treatment
At Bramley Pharmacy, we support patients by offering tailored guidance on how to reduce the risk of gallstone formation during weight loss. This includes:
- Gradual Weight Loss
Aim to lose weight slowly and consistently — generally no more than 1–2 lbs per week. - Stay Well Hydrated
Water supports bile flow and healthy liver and gallbladder function. - Maintain Regular Eating Patterns
Skipping meals or long fasting periods can increase the risk of bile stasis. Structured meal timing is encouraged. - Include Small Amounts of Healthy Fats
Moderate intake of healthy fats like olive oil, nuts, and avocados can stimulate gallbladder function. - Know the Symptoms
Be aware of early signs of gallbladder stress so that issues can be addressed promptly.
Our Clinical Weight Management Approach
Our face-to-face, pharmacist-led service includes:
- Clinical assessments and screening
- Ongoing medical reviews and side-effect monitoring
- Personalised lifestyle and dietary advice
- Blood testing where appropriate
- Support with symptom tracking and management
We do not advertise or promote any specific prescription-only medicine (POM). All treatments are prescribed based on individual clinical need following a consultation.
Final Thoughts
While gallbladder issues are a potential side effect of weight loss — regardless of how it’s achieved — risks can be managed with the right guidance and monitoring. By supporting patients with clear education, nutritional advice, and regular check-ins, our team at Bramley Pharmacy helps ensure treatment is both safe and effective.
If you’re considering starting a GLP-1/GIP-based weight management plan — or are already on treatment and want to ensure you’re receiving appropriate clinical support — book a consultation today.
📍 Visit us: Bramley Pharmacy, 261 Northfield Avenue, Ealing, W5 4UA
📞 Call us: 0208 840 4464
🌐 Book online: www.bramleypharmacy.com
